Cardiovascular diseases remain the leading cause of death worldwide
Heart Failure
Heart failure is a complex clinical syndrome in which the heart is unable to pump sufficient blood to meet the body’s needs. It commonly develops as a consequence of myocardial infarction, where the loss of oxygen supply leads to irreversible damage of cardiac tissue and progressive decline in function.
This condition affects more than 64 million people globally, with millions of new cases diagnosed annually. It is associated with high morbidity and mortality, with nearly 50% of patients dying within five years of diagnosis, and represents a major driver of hospitalizations and healthcare costs.
The burden of heart failure continues to increase due to population aging, improved survival after acute cardiac events such as myocardial infarction, and the rising prevalence of chronic conditions including hypertension, diabetes, and obesity. Together, these factors are driving a sustained growth in disease incidence and placing increasing pressure on healthcare systems worldwide.
THE CLINICAL GAP
Despite advances in cardiovascular care, current therapies do not address the underlying loss of functional cardiac tissue.
Irreversible Tissue
Damage
Following myocardial infarction, a large number of cardiomyocytes are permanently lost.
The adult heart has a very limited ability to regenerate, making this damage largely irreversible.
Scar
Formation
Damaged tissue is replaced by non-contractile scar tissue, which compromises the mechanical function of the heart.
This leads to reduced contractility and progressive deterioration.
Lack of Regenerative Therapies
Current treatments focus on symptom management and slowing disease progression.
There are no available therapies capable of restoring functional cardiac tissue.